2022-05-16 Speech notes for the Toronto Board of Health

The Truckers would do a better job running TPH

I address these comments particularly to my councillor, Mr Paul Ainslie. Please see https://f2sg.substack.com/p/2022-05-16-speech-notes-for-the-toronto for the notes and references for this speech.

This is an attempt to summarize a paper from 2022-01-22 titled https://www.researchgate.net/publication/357994624_Innate_Immune_Suppression_by_SARS-CoV-2_mRNA_Vaccinations_The_role_of_G-quadruplexes_exosomes_and_microRNAs. The paper describes how mRNA SARS-CoV-2 vaccines act differently from the natural infection and may be counterproductive to both short- and long-term immunity. Stephanie Seneff, one of the paper’s authors discusses the paper at a high level on https://thehighwire.com/videos/mit-scientist-connects-mrna-shots-to-brain-disease/

Differences between the mRNA vaccines and SARS-CoV-2 infection

The design goal of the mRNA vaccines is to stimulate the immune system to produce antibodies against the virus. The vaccine mRNA has a number of changes from the native SARS-CoV-2 virus in order to evade the immune system and get into cells to start producing spike proteins to trigger the body’s production of antibodies.

Both mRNA vaccines replace uridine in the spike protein with 1-methylpseudouridine to essentially abolish the immune toll receptor response to the vaccine mRNA. Additional slight alterations to the sequences also increase the stability of the mRNA. Nanolipid encapsulation also helps to evade the normal immune response to exogenous RNA in order to encourage production of spike proteins.

This does allow the mRNA to enter cells and generate spike proteins but with the consequence that the vaccines can generate spike protein in the body, longer than the native infection.

Both mRNA vaccines have more Guanine codons than native SARS-CoV-2 mRNA. The altered codon assignments within the mRNA template dramatically increase the quantity of polypeptides and/or proteins produced.

Impairment in type I interferon signaling subverts innate immunity

An important communication network among cells consists of extracellular vesicles (EVs) known as exosomes, formed inside endosomes, similar in size to viruses, and released through exocytosis into the extracellular space to subsequently circulate throughout the body. Spike proteins generated in cells can leave the cell via exosomes. It has been found experimentally that exosomes carrying vaccine generated spike protein also carry microR-148a and microR-590 microRNAs. There is a proposal that these microRNAs disrupt type I interferon signaling through suppression of two critical proteins that control the pathway. Impaired type I IFN signaling is linked to many disease risks, most notably cancer, as type I IFN signaling suppresses proliferation of both viruses and cancer cells by arresting the cell cycle.

The miR-148a and miR-590 microRNAs were not found in exosomes of those who experienced the native SARS-CoV-2 virus. Vaccination therefore may actively suppresses type I IFN production whereas natural infection promotes type I IFN production very early in the disease cycle.

“Those with preexisting conditions often exhibit impaired type I IFN signaling, which leads to more severe, critical, and even fatal COVID-19. If the impairment induced by the vaccine is maintained as antibody levels wane over time, this could lead to a situation where the vaccine causes a more severe disease expression than would have been the case in the absence of the vaccine.”

Potential disturbances in regulatory control of protein synthesis

The Guanine/Cytosin codon enrichment to enhance the body’s expression of the vaccinal mRNA results in an enhanced ability for potential G quadruplex (pG4) formations. This may lead to protein misfolding and on to prion and neurodegenerative diseases such as Creutzfeldt–Jakob, Alzheimer’s, Parkinson’s, ALS. If pG4s accumulate, as would be expected with an increased amount of Guanine/Cytosine content in the vaccine mRNA, this would have an effect of increasing potential G4 structures available during translation events and this can affect microRNA post-transcriptional regulation. This, in turn, would either favor greater expression of the oncogenes related to a range of cancers or drive cells to apoptosis and cell death.

Conclusions

There is considerable evidence that the mRNA vaccines increase susceptibility to new variants of SARS-CoV-2 and there are signals for excess mortality among the vaccinated. Of course the theories in this paper are preliminary but they are attempting to explain a real issue and merit further research.

The immune system is exceptionally complicated and fine tuned. The underlying message in this paper is that every intervention in the immune system has consequences. It’s complete hubris to think we understand all the consequences of the mRNA vaccines. Given their doubtful efficacy against recent variants it’s high time for Toronto Public Health to stop advocating these vaccines and start properly studying the effects of the doses already given.